VON WILLEBRAND DISEASE TYPE I
Description
Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding during veterinary procedures; your veterinarian should be informed so that appropriate blood products are at hand in case a transfusion is required. Affected dogs may also require close monitoring during their daily lives. If informed of your dog’s condition early, you and your veterinarian can discuss precautionary measures now.
Von Willebrand Disease (vWD) causes easy bruising and excessive bleeding from small cuts and nicks; you may also observe blood in your dog’s stool or urine. Affected dogs are also at risk for excessive bleeding during surgery. Von Willebrand Factor is exposed on tissue surfaces upon tissue injury, where it is recognized by platelets and other clotting factors, thus triggering the clotting cascade. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal vWF multimer composition, and mild to moderate clinical signs.
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